Biodegradable Harmonophores for Targeted High-Resolution In Vivo Tumour Imaging

On Demand

Dr Periklis Pantazis

Reader in Advanced Optical Precision Imaging Imperial College London

Read Bio

Nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents because of minimal background signal and long-term photostability. In this talk, Laki shows how biodegradable harmonophores (bioharmonophores) were developed to overcome the health concerns of inorganic SHG nanoprobes, and can target single cancer cells with high detection sensitivity in zebrafish embryos in vivo.

This presentation was recorded as part of the 4th virtual edition of the Leica Microsystems “See the Hidden” Workshop Series, hosted by Microscopy Focus. In collaboration with Imperial College London (ICL) and the Imperial College Network of Excellence in Cancer Technology, this joint event showcased how a multidisciplinary research approach is creating innovative new ideas for the detection, prevention, and ultimately the treatment of cancer.

Image: Magma bioharmonophores
“Spherism” rendition of triphenylalanine bioharmonophores captured by TEM. The cores of the probes feature an artistic representation of their molecular components, triphenylalanine molecules. Courtesy of Mr. Konstantinos Kalyviotis, Research Postgraduate in Periklis Pantazis’ group at ICL.

Access this content

Login

If you have previously registered on Microscopy Focus

or Register

First Name*

Last Name*

Email Address**

Company or Organisation*

Job Title

Postal Code*

Select Country*

What is your primary interest?**

* denotes mandatory fields.

I give Leica Microsystems, Bitesize Bio and their affiliates permission to provide me with information about their products and services. I understand that I may be contacted by phone or email.*

Name

This field is for validation purposes and should be left unchanged.