See the Hidden: Adding Time to the Correlative Equation

On Demand

Learn how to stimulate and synchronize subcellular events using light and electricity and discover workflow solutions for correlative imaging that enable time stamping of dynamic biological events during high-resolution EM imaging.

In this webinar, you will learn:

  • Methods to trigger subcellular events with light or electrical stimulation, and capture them with CLEM;
  • How to use correlative EM to extract three-dimensional data within a temporal context;
  • About Leica’s Coral Life Live Cell CLEM workflow solution and how it can timestamp dynamic biological events.

In the next virtual edition of our See the Hidden Workshop series, we show you how Leica’s workflow solutions for correlative imaging enable you to add a timestamp to a dynamic biological event while capturing it with high-resolution EM imaging.

With the help of leading researchers, we explore how CLEM workflows can help capture dynamic events, such as neurotransmission at the synapse, and how optical and electrical stimulation can trigger and synchronize cellular processes right before vitrification.

The first session focuses on Live Cell CLEM workflows, where cutting-edge techniques open doors to observing dynamic cellular processes. Featuring renowned experts Paul Verkade, Nalan Liv, and Leica’s Frédéric Leroux, this session will shed light on the convergence of live cell imaging and electron microscopy.

The second session will emphasize using CLEM workflows involving light and electrical stimulation. Correlative imaging experts Joachim Greiner and Jana Kroll will guide you through innovative methods and their latest research findings.

Discover how such approaches allow researchers to trigger and capture subcellular events such as neuron endocytosis with exceptional precision. Both sessions will conclude with an interactive panel discussion between the speakers.


13:00 GMT | 14:00 CET — Session 1: Live Cell CLEM workflows

Scientific Presentations followed by live Q&A:

  • Paul Verkade, University of Bristol, UK
  • Nalan Liv, UMC Utrecht, The Netherlands
  • Frédéric Leroux, Leica Microsystems, Belgium

14:40 GMT | 15:40 CET — Coffee Break

14:50 GMT | 15:50 CET — Session 2: Capturing Ultra-Fast Processes

Scientific Presentations followed by live Q&A:

  • Joachim Greiner, Universitäts-Herzzentrum Freiburg, Germany
  • Jana Kroll, Max Delbrück Center for Molecular Medicine, Germany
  • Frédéric Leroux, Leica Microsystems, Belgium

16:00 GMT | 17:00 CET — Closing Remarks

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