Integrated Solutions for Serial Sectioning and Cryo-EM with UC Enuity

Andreia Pinto

Advanced Workflow Specialist, Leica Microsystems

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Dr Pinto started her career as a Biomedical Scientist in Histocellular Pathology with a particular interest in electron microscopy. In 2014, she worked at the Primary Ciliary Diagnosis (PCD) in Lisbon. In 2019, Andreia moved to the Royal Brompton Hospital, London, working as a Thoracic Research Associate, where she was responsible for training a deep machine learning platform to recognize patterns in EM images of cilia in diagnosing PCD. She completed her PhD on this topic in 2022 while also investigating new insights into SARS-CoV-2 infection of the respiratory airway. Andreia is currently an Advanced Workflow Application Specialist with Leica Microsystems, based at the Imaging Centre of the European Molecular Biology Laboratory (EMBL) in Heidelberg.

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Adrian Boey

PhD Application specialist, Singapore, Leica Microsystems

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Adrian Boey obtained his PhD on the gene regulation of Cytochrome P450s from the University of Melbourne in 2011. He has worked in a diverse range of fields, from genetics to microbiology and electron microscopy. He is the applications specialist for EM Sample Preparation equipment and Cell DIVE South-East Asia and Taiwan for Leica Microsystems and has a strong interest in EM and spatial biology.

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Hoyin Lai

Application Development Manager, Leica Microsystems

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Hoyin studied Bioengineering at the University of Washington, Seattle, USA, where he designed a single-stroke peristaltic pump for fluid delivery in microfluidic devices. He joined the Aivia team in 2010 as an Application Engineer. Since launching Aivia in 2017, Hoyin is focused on applying artificial intelligence (AI) techniques to develop image analysis solutions for life science researchers.

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Discover integrated solutions for precise serial sectioning and cryo-EM sample prep—supporting seamless workflows from ultramicrotomy to 3D electron microscopy.

In this webinar, you will learn:

• How to streamline serial sectioning for volume EM using the UC Enuity and AT module
• How to achieve in-situ targeting under cryogenic conditions for cryo-EM workflows;
• How integrated imaging and AI-powered analysis enhance 3D EM data interpretation.

Join us for a webinar that explores the power of Leica Microsystems’ UC Enuity ultramicrotome at the core of cutting-edge electron microscopy (EM) workflows.

This session will showcase two distinct applications of the system, highlighting its versatility in both room temperature and cryogenic sample preparation.

The first presentation focuses on Volume EM, demonstrating how the AT module of the UC Enuity enables the precise preparation of serial ultrathin sections.

These sections can then be imaged using an SEM and analyzed using Aivia, Leica’s AI-powered image analysis platform, illustrating a fully integrated workflow from sectioning to visualization and quantification.

In the second part of the webinar, we shift focus to cryo-electron microscopy, where the Cryo UC Enuity, equipped with the M205 stereomicroscope, plays a key role in in-situ targeting under cryogenic conditions.

Used alongside the EM ICE high-pressure freezer and the STELLARIS Cryo confocal platform, this solution supports correlative imaging and targeting for cryo-electron tomography.

Whether your work involves structural biology, cell biology, or neuroscience, this webinar will demonstrate how Leica’s end-to-end solutions can support high-resolution, high-precision 3D EM workflows.