Imaging GPCR Activity: Unravelling Mechanisms from Molecules to Morphology

Aylin Hanyaloglu

Professor in Molecular Medicine, Imperial College London

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Professor Hanyaloglu has been a Group Leader at Imperial College London since 2007 and a Satellite Group Leader at The Francis Crick Institute since 2022. She received her BSc in Human Biology from King’s College London and a Ph.D. in Molecular Endocrinology from the University of Western Australia, undertaking postdoctoral training at the University of California, San Francisco. Her research focuses on mechanisms directing G protein-coupled receptor activity in diverse physiological/pathophysiological systems.

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Aanya Hirdaramani

PhD Student, Imperial College London

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Professor Hanyaloglu has been a Group Leader at Imperial College London since 2007 and a Satellite Group Leader at The Francis Crick Institute since 2022. She received her BSc in Human Biology from King’s College London and a Ph.D. in Molecular Endocrinology from the University of Western Australia, undertaking postdoctoral training at the University of California, San Francisco. Her research focuses on mechanisms directing G protein-coupled receptor activity in diverse physiological/pathophysiological systems.

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See the latest cutting-edge imaging techniques to understand how GPCR signaling translates into cellular and physiological responses to pave the way for targeted drug development in pharmacology, endocrinology, and metabolism research.

In this webinar, you will learn:

• Insights into the current models of GPCR signaling
• How imaging applications have contributed to a new understanding of GPCR activity
• The limitations and future directions of understanding GPCR signaling from tool and technology platform levels

Precise control of cellular communication and signaling is crucial for every physiological system, with G protein-coupled receptors (GPCRs, the largest family of signaling receptors) playing a central role as essential molecular sensors of a cell’s environment.

Because of their diverse physiological and pathophysiological roles, GPCRs are also major drug targets.

Our understanding of GPCR signaling has evolved from single receptors at the cell surface activating specific heterotrimeric G protein pathways, to an increasingly complex receptor signaling system.

However, how such complexity in GPCR signaling is translated to specific cellular and physiological responses is still unclear.

Understanding these mechanisms is an area of precedence due to the intense interest in identifying GPCR modulators with high specificity in action.

In this webinar, we will discuss some of our endeavors to uncover these molecular mechanisms through a wide range of imaging applications to study GPCRs across scales from single molecules to identification of new subcellular signal platforms and the downstream cellular significance of receptor location to fundamental cellular functions.

This session will be relevant to scientists in cell biology, pharmacology, endocrine, and metabolism.