Democratizing Nanoscale Imaging at Molecular Resolution

Dr. Ali Shaib

Group Leader, University Medical Center Göttingen

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Dr. Ali Shaib is a Group Leader at the University Medical Center Göttingen, where he leads a multidisciplinary team working at the interface of structural biology, diagnostics, and artificial intelligence. His research has been recognized internationally, with Nature describing his work as “democracy in microscopy” and “a technology to keep an eye on".

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Discover a practical expansion imaging approach that reveals protein shape and spatial organization at the nanoscale using standard fluorescence microscopy.

In this webinar, you will learn:

• How ONE microscopy works: The principles behind sample expansion, amino‑acid labeling, and achieving molecular‑scale resolution using conventional microscopes
• How to visualize proteins with sub‑nanometer precision: Enabling detailed shape analysis of purified proteins in solution
• About nanoscale mapping in cells and tissues: Identifying proteins and determining their spatial localization within native ultrastructural environments
• Application insights: How ONE microscopy can support studies in fields such as neurodegeneration and cancer by revealing ultrastructural protein context

Achieving molecular‑level resolution has long required advanced, highly specialized technologies such as cryo‑EM—making the structural imaging of individual proteins inaccessible to most researchers.

This webinar introduces One‑step Nanoscale Expansion (ONE) microscopy, a transformative and practical method that delivers sub‑nanometer resolution using standard fluorescence microscopes. By physically expanding samples and labeling amino acids with conventional fluorophores, ONE microscopy makes it possible to visualize protein shape in free solution and map protein identity and spatial organization inside cells and tissues.

This webinar is ideal for researchers seeking high‑resolution structural insights without the cost or complexity of cryo‑EM or other advanced platforms. ONE microscopy significantly lowers the technical threshold for molecular‑scale imaging, making powerful structural biology tools more accessible than ever.

This session will equip you with a cutting‑edge yet practical approach to expanding your nanoscale imaging capabilities across fundamental biology, disease‑mechanism research, and imaging technology development.